Italian wine is produced in every region of Italy, home to some of the oldest wine-producing regions in the world. Italy is the world's largest producer of wine, with an area of 702,000 hectares (1,730,000 acres) under vineyard cultivation, and contributing a 2013–2017 annual average of 48.3 million hl of wine. In 2018 Italy accounted for 19 percent of global production, ahead of France (17 percent) and Spain (15 percent). Italian wine is both exported around the world and popular domestically among Italians, who consume an average of 42 litres per capita, ranking fifth in world wine consumption.

Etruscans and Greek settlers produced wine in Italy before the Romans planted their own vineyards in the 2nd century AD. The Romans greatly increased Italy's area under vine using efficient viticultural and winemaking methods, and pioneered large-scale production and storage techniques such as barrel-making and bottling.